Soko Cheng '19 has been awarded a competitive Gilman International Scholarship, which she will use this sprin...
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Professor & Chair of Biochemistry
2 East South Street
Galesburg, IL 61401-4999
Professor of Chemistry
"The general research interest for my laboratory is on protein structure and how the final 3-D structure is obtained; what provides stability to a protein and how does a newly synthesized protein fold into its final shape? We use a protein from E. coli called GrpE as a model protein to try to answer questions about folding and stability because it has some common and unique structural characteristics.
Additionally, I've started exploring a new research area called protein design. I'm interested in using some of the properties we found with the GrpE protein to create a brand new protein molecule that has the potential to self assemble into a much large entity: a protein nanoring. These nanostructures will have potential use in biomedical and bioelectronic applications."
Years at Knox: 1993 to present
Ph.D., Biochemistry, 1990, University of Maryland.
B.A., Chemistry and Biology, magna cum laude, 1985, McDaniel College.
General chemistry, biochemistry, proteins and enzymes, methods in biochemistry, biological spectroscopy.
Full Curriculum Vitae - (DOC)
"Determination of Myoglobin Stability by Circular Dichroism Spectroscopy: Classic and Modern Data Analysis", coauthored with Mary A. Crawford, and Lie Zhang. Journal of Chemical Education (2009).
"A Water Meditated Electrostatic Interaction Gives Thermal Stability to the 'Tail' Region of the GrpE Protein from E. Coli." Co-authored with B. Demeler, and A. Zraikat. The Protein Journal (2006).
"Insights into Dimerization and Four-Helix Bundle Formation Found by Dissection of the Dimer Interface of the GrpE Protein from E. coli." Co-authored with Luke D. Heskett, Sumesh S. Jain, and Borries Demeler. Protein Science 12 (2003): 1205.
"A GrpE Mutant Containing the NH-2-Terminal 'Tail' Region is able to Displace Bound Polypeptide Substrate from DnaK." Co-authored with Luke D. Heskett, '00, and Kristina M. Neal, '99. Biochemical and Biophysical Research Communications 282 (2001): 562.
With M. Crawford and J. Templeton. Creating Opportunity and Access in Science and Technology. Envisioning the Future of Undergraduate STEM Education (EnFUSE): Research and Practice. Washington, D.C. April 27 - 29, 2016.
"Probing Dimer Interface Surface Requirements via Internal Deletion Mutations within the GrpE Protein." Poster, 23rd Symposium of the Protein Society, 2009.
Campus & Community Involvement
What Students Say
"Professor Mehl combines an innate ability to work informally with students and a characteristic I like to call comfortable professionalism. His ability and attitude towards working with students is best exemplified by the number of students who have expressed great interest in conducting research for him. Andrew has allowed me to follow my own direction in scientific research, while guiding me along the correct path."
-Bevin Philip, biochemistry and chemistry major