Knox College Model United Nations (KMUN) is designed to give students the opportunity to explore and implement the tools of international diplomacy and political compromise. This popular and accomplished club exemplifies the "freedom to flourish" quality that Knox so proudly stands for.

The club participates in both intercollegiate competitive Model United Nations and the Model Arab League simulations around the world where students, as a delegation of the college, represent a particular country or number of countries in the different United Nations committees.

The Knox Model UN Club has participated in conferences in the United States and abroad. The club has won awards at the McGill Conference in Montreal—one of the most prestigious conferences in North America—as well as a national conference held in Chicago and international conferences in Europe and Egypt.