Years at Knox: 1981 to present.
Education
Ph.D., Physics, 1979, University of Illinois at Urbana-Champaign.
M.S., Physics, 1973, University of Illinois at Urbana-Champaign.
B.A., Physics, magna cum laude, 1972, Knox College.
Professional Interests
"My research is in molecular biophysics, an area that overlaps physics, chemistry and biology. I use spectroscopy -- study of the molecule's physical properties by measuring the wavelengths of electromagnetic radiation absorbed -- as a tool in working toward understanding how metalloproteins' structure allows them to perform their specific catalytic activities. Specifically, I use Mössbauer Spectroscopy, in which we measure the absorption of gamma rays by the nucleus of the iron found at the active site of many proteins. A good example is the hemoglobin protein, an iron-based molecule that carries oxygen in the blood.
Knowing the relationship between a protein's structure and its function is essential to understanding the operation of living systems. It also has the potential to aid in the treatment of genetic diseases. Several of our undergraduate physics majors have been helpful collaborators in my research, both in developing the apparatus for collecting data and in developing computer software for data analysis."
Teaching Interests
Introductory physics, physics of music, classical dynamics, quantum mechanics, digital electronics, astronomy, modern physics, theoretical physics
Recent Scholarly Achievements
Publications
"New Insights on the Electronic and Molecular Structure of Cyanide-Ligated Iron(III) Porphyrinates." Coauthored with Jiangfeng Li, Bruce C. Noll and W. Robert Scheidt. Inorganic Chemistry 46 (2007): 2286-2298.
"Four-Coordinate Iron(II) Porphyrinates: Electronic Configuration Change by Intermolecular Interaction." Coauthored with Chuanjiang Hu and W. Robert Scheidt. Inorganic Chemistry 46 (2007): 619-621.
"Electronic Configuration of High-Spin imidazole-Ligated Iron(II) Octaethylporphyrinates." Coauthored with C. Hu, J. An, W.R. Scheidt, and B.C. Noll. Inorganic Chemistry 45 (2006): 4177-4185.
"Coordination of Diatomic Ligands to Heme: Simply CO." Coauthored with N.J. Silvernail, W.R. Scheidt, and B.C. Noll. Inorganic Chemistry 45 (2006): 7050-7052.
"'Low-Spin BIS(2-methylimidazole) (octaethylporphyrinato) iron(II) Choloride (perp-[Fe(OEP)(2-MeHIm)2]Cl): A Consequence of Hydrogen Bonding?" Inorganic Chemistry 45 (2006): 9721-9728.
"On Spin Hamiltonian fits to Mossbauer spectra of high-spin Fe(II) porphyrinate systems." Coauthored with Chuanjiang Hu and W. Robert Scheidt. Hyperfine Interactions 170 (2006): 55-60.
"Fe Vibrational Spectroscopy of Myoglobin and Cytochrome f." Coauthored with Kristl L. Adams, Stanslav Tsoi, Jiusheng Yan, Stephen M. Durbin, Anant K. Ramdas, William A. Cramer, Wolfgang Sturhahn and E. Ercan Alp. Journal of Physical Chemistry B 110 (2006): 530-536.
"Proton-mediated Electron Configuration Change in High-Spin Iron(II) Porphyrinates." Coauthored with Chuanjiang Hu, Bruce C. Noll and W. Robert Scheidt. Journal of the American Chemical Society 127 (2005): 15018-15019.
"Heme Carbonyl: Environmental Effects on nC-O and Fe-C/C-O Bond Length Correlations." Coauthored with Nathan J. Silvernail, Arne Roth, Bruce C. Noll and W. Robert Scheidt. Journal of the American Chemical Society 127 (2005): 14422-14433.
"Electronic Configuration Assignment and the Importance of Low-Lying Excited States in High-Spin Imidazole-Ligated Iron(II) Porphyrinates." Co-authored with Knox student Christina Ellis '05 and C. Hu, A. Roth, M.K. Ellison, J. An, and W.R. Scheidt. Journal of the American Chemical Society 127 (2005): 5675-5688.
"Ligand Orientation Control in Low-Spin Six-Coordinate (Porphinato)iron(II) Species." Coauthored with Chuanjiang Hu, Bruce C. Noll and W. Robert Scheidt. Inorganic Chemistry 44 (2005): 4346-4358.
"Variable π-Bonding in Iron(II) Porphyrinates with Nitrite, CO, and tert-Butyl Isocyanide: Characterization of [Fe(TpivPP)(NO2)(CO)]–." Coauthored with Habib Nasri, Mary K. Ellison, Maoyu Shang, and W. Robert Scheidt. Inorganic Chemistry 43 (2004): 2932-2942.
"Five- to Six-Coordination in (Nitrosyl)iron(II) Porphyrinates: Effects of Binding the Sixth Ligand." Coauthored with Graeme R.A. Wyllie and W. Robert Scheidt. Inorganic Chemistry 42 (2003): 5722-5734.
"Effect of the Sixth Axial Ligand in CS-Ligated Iron(II)octaethylporphyrinates: Structural and Mössbauer Studies." Coauthored with Changsheng Cao, Sanjay Dahal, Mayou Shang, Alicia M. Beatty, Wendy Hibbs, and W. Robert Scheidt. Inorganic Chemistry 42 (2003): 5202-5210.
"Five-to Six-Coordination in (Nitrosyl)iron(II) Porphyrinates: Effects of Binding the Sixth Ligand." Coauthored with Graeme R.A.W. Wyllie and W. Robert Scheidt. Inorganic Chemistry 42 (2003): 5722-5734.
"Effect of the Sixth Azial Ligand in CS-Ligated Iron(II)octaethylporphyrinates: Structural and Mössbauer Studies." Coauthored with Changsheng Cao, S. Dahal, Mayou Shang, Alicia M. Beatty, Wendy Hibbs and W. Robert Scheidt. Inorganic Chemistry 42 (2003): 5202-5210.
"Mössbauer Studies of Fe(II)-nitrosyl Porphyrin Model Compounds." Coauthored with Graeme R.A. Wyllie and W. Robert Scheidt. Hyperfine Interactions (C) 5 (2003): 321-324.
"Nitrosyliron(III) Porphyrinates: Porphyrin Core Conformation and FeNO Geometry. Any Correlation?" Coauthored with Mary K. Ellison and W. Robert Scheidt. Journal of the American Chemical Society 124 (2002): 13833-13841.
"Structure of the Deoxymyoglobin Model [Fe(TPP)(2-MeHIm)] Reveals Unusual Porphyrin Core Distortions." Coauthored with Mary K. Ellison and W.Robert Scheidt. Inorganic Chemistry 41 (2002): 2173-2181.
"Unexpected Nitrosyl-Group Bending in Six-Coordinate {M(NO)}6 Bonded Aryl(iron) and –(ruthenium) Porphyrins." Coauthored with George B. Richter-Adoo, Ralph A. Wheeler, Christopher A. Hixson, Li Chen, Masood A. Khan, Mary K. Ellison, and W. Robert Scheidt. Journal of the American Chemical Society 123 (2001): 6314-6326.
"Molecular Structure of an Fe(IV) Species: {[Fe(TTP)]2N}SbCl6." Coauthored with Ming Li, Maoyu Shang, Noelle Ehlinger, and W. Robert Scheidt. Inorganic Chemistry, 2000.
"Magnetic Interactions in the High-Spin Iron(III) Oxoocctaethylchorinato [Fe(oxoOEC)(Cl)] and its π-Cation Radical [Fe(oxoOEC)(Cl)SbCl6." Coauthored with Teresa J. Neal, Seong-Joo Kang, Ilona Turowska-Tyrk, and W. Robert Scheidt. Inorganic Chemistry, 2000.
"Syntheses, Characterization, and Structural Studies of Several (Nitro)(nitrosyl)iron(III) Porphyrinates: [Fe(Porph)(NO2)(NO)]." Coauthored with Mary K. Ellison and W. Robert Scheidt. Inorganic Chemistry 38 (1999): 100-108.
"Aggregated Heme Detoxification Byproducts in Malarial Trophozoites: b-Hematin and Malaria Pigment Have a Single S=5/2 Iron Environment in Bulk Phase as Determined by EPR and Magnetic Mössbauer Spectroscopy." Coauthored with D. Scott Bohle, Peter Debrunner, Peter A. Jordan, and Sara K. Madsen. Journal of the American Chemical Society 120 (1998): 8255-8256.
"An Experimental and Density Functional Theoretical Investigation of Iron-57 Mössbauer Quadrupole Splittings in Organometallic and Heme-Model Compounds: Applications to Carbonmonoxy-Heme Protein Structure." Coauthored with R.H. Havlin, N. Godbout, R. Salzmann, J. Wojdelski, W. Arnold and E. Oldfield. Journal of the American Chemical Society 120 (1998): 3144-3151.
Presentations
"Mössbauer Studies of Fe(II)-nitrosyl Porphyrin Model Compounds." International Conference on Applications of the Mössbauer Effect, Oxford University, U.K., 2001.
Recognitions
Awards
Distinguished Service Citation, Illinois Section of the American Association of Physics Teachers (ISAAPT), 2004.
Involvement
President of American Association of Physics Teachers, Illinois Section, 2001.
Member, Phi Beta Kappa; Sigma Xi - The Scientific Research Society.
Member, American Physical Society, American Association of Physics Teachers, Council on Undergraduate Research, American Association for the Advancement of Science.
International EPR Society.
|
